Cellular Target Profiling™

The Kinaxo Cellular Target Profiling™ service delivers powerful insights into small molecule target interactions and binding affinities across the proteome of any given cell line or tissue sample. This information significantly supports decision making at various stages of the drug development process, e.g. lead compound selection, target deconvolution, drug reprofiling, and off-target toxicity assessment. Kinaxo's chemical proteomics technology was recently featured in EuroBiotechNews (pdf). Further information can be downloaded below.

Knowledge of a compound’s native protein target profile enables development programs to reach high confidence levels regarding in vivo selectivity and mode of action. Now, Kinaxo makes it easy to secure this advantage with its patented Cellular Target Profiling™ technology.

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NEWS & EVENTS

Apr 29, 2009
KINAXO’s Cellular Target Profiling^® reveals mTOR as a new target of Celebrex^® more..

Feb 24, 2009
Kinaxo contributes its quan-
titative phosphoproteomics platform to a drug efficiency study more..

Oct 15, 2008
KINAXO enters into US and Japanese partnerships to introduce its Cellular Target Profiling™ Service. more..

Oct 13, 2008
Kinaxo Enters into an Agreement with Boehringer Ingelheim. more..

July 24, 2008
Kinaxo Biotechnologies Awarded Grant to Expand Applications for its Chemical Proteomics Platform. more..

The Kinaxo Cellular Target Profiling™ service employs state-of-the-art chemical proteomics methods combined with the latest quantitative mass spectrometry techniques to deliver a complete picture of your compound's proteomic target interactions:

Identify all protein targets that interact with a small molecule within a cell line or tissue proteome

Rank cellular compound/target binding affinities across a broad dynamic range

Profile small molecules against native cellular derived proteins

Unveil target interactions not revealed by in vitro panel profiling

In collaboration with the Max Plank Institute for Biochemistry, Kinaxo has developed optimized and validated methods that deliver reliable and reproducible results which can be immediately applied to the successful management of small molecule drug development programs.

We invite you to browse our website to learn more about our services. Please feel free to contact our international service specialists to arrange a webinar or on-site presentation.